Combined analgesic effect of morphine and ketamine
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چکیده
منابع مشابه
Effect of glutamic acid and ketamine on morphine-induced analgesic response in rats.
Rats were treated with intraperitoneal injections of morphine (10 mg/kg) followed by glutamic acid (20 mg/kg.) and ketamine. (5 mg/kg). Pain thresholds were recorded as tail flick latencies for a period of 23 days and the mean area under curves calculated. Glutamic acid and ketamine, partially blocked the analgesic effects of morphine. Two types of effects were observed. In 4 animals, there was...
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BACKGROUND Pain is a common condition among prehospital patients. The present study is designed to determine whether adding low-dose ketamine as additional analgesia improves the pain/nausea scores and hemodynamic parameters compared to morphine sulphate alone among patients with bone fractures. METHODS Prospective, prehospital clinical cohort study. Twenty-seven patients were included with a...
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Introduction: Several researches have reported that stress is able to inhibit the development of morphine tolerance via activating of Hypothalamic-Pituitary-Adrenal (HPA) axis. In the present study we tried to examine the effect of epinephrine, the product of adrenal medulla, on the development of morphine tolerance. Methods: Analgesic tolerance was induced by intrathecal (i.t.) injection of...
متن کاملRelative contribution of morphine and morphine-6-glucuronide to the analgesic effect after morphine administration.
Editor—We thank Dahan and Lotsch for their interest in our review and their valuable comments to the discussion about the role of morphine-6glucuronide (M6G), for the analgesic effect after morphine administration. Because morphine is used worldwide as the potent standard analgesic drug, with the formation of an even more potent metaboliteM6G, it is important to elucidate the relative contribut...
متن کاملPharmacokinetics and analgesic effect of ketamine in man.
The pharmacokinetics and analgesic effect of i.v. ketamine in doses of 125 microgram kg-1 and 250 microgram kg-1 were determined in five healthy volunteers. Analgesia was measured with the submaximal effort tourniquet test. Both doses of ketamine prolonged the period of pain-free ischaemic exercise while the plasma ketamine concentration was greater than 100 ng ml-1. Ketamine was distributed ra...
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ژورنال
عنوان ژورنال: Anaesthesia
سال: 1995
ISSN: 0003-2409,1365-2044
DOI: 10.1111/j.1365-2044.1995.tb06119.x